Flammability of the product autoignition temperature not available. Partb simultaneous reverse phase high performance liquid. The c max and auc increase approximately linearly with dose after both single administration and under steadystate conditions. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. A material safety data sheet msds is required under the u. View detailed export data, price, monthly trends, major exporting countries, major ports of deferasirox under hs code 2933. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Safety data sheet california carb compliant 1 identification product name.
S705 january 2009 with 32 reads how we measure reads. Identification of the substancemixture and of the companyundertaking 1. Preparation of the 22hydroxyphenyl1, 3 benzoxazinone compound 2. First aid measures description of first aid measures. Lubricant, penetrant, drives out moisture, removes and protects surfaces from corrosion restrictions on use.
Do not take exjade with aluminumcontaining antacid products. Buy deferasirox d4 cas 13425758, a labeled tridentate iron chelator, from santa cruz. Accidental release measures contain spill and collect, as appropriate. Deferasirox loaded on fumed silica nanoparticles used in. List of drug master files dmf of active pharmaceutical ingredients apis submissions by msn laboratories pvt ltd to the u. Deferasirox according to regulation ec no 19072006, annex ii, as amended. Deferasirox inhibited the growth of all four gastric cancer cell lines in a dosedependent and timedependent manner fig. The information given is designed only as a guidance for safe handling, use, processing, storage. M, all subsequent experiments were performed using these cells. If youre not able to select an item from this list, it means the item is restricted and cannot be ordered online as we first need to ensure that dea requirements are fulfilled. Msds material safety data sheet nfpa national fire protection association niosh national institute for occupational safety and health ntp national toxicology program rapidpatch tm 11.
Immediately wash skin with soap and plenty of water for at least 15 minutes. Most developed countries have similar regulations and requirements. List of drug master files dmf of cefuroxime axetil active pharmaceutical ingredient api submitted to the u. Calculate doses mgkg per day to the nearest whole tablet. Pharmaceutical component list active pharmaceutical ingredients. Deferasirox is a member of the class of triazoles, deferasirox is 1,2,4triazole substituted by a 4carboxyphenyl group at position 1 and by 2hydroxyphenyl groups at positions 3 and 5. Dailymed exjade deferasirox tablet, for suspension. Msn laboratories pvt ltd dmfs us drug master file dmf. Its main use is to reduce chronic iron overload in patients who are receiving longterm blood transfusions for conditions such as betathalassemia and other chronic anemias. Randomized phase ii trial of deferasirox exjade, icl670, a oncedaily, orallyadministered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload.
Exjade deferasirox tablets for oral suspension 4, 5. Oct 20 section i product and company identification weldon p70 low voc primer for pvc and cpvc plastic pipe low voc primer for pvc and cpvc plastic pipe manufacturer. Do not take antacids that have aluminum in them with this medicine deferasirox tablets. Take exjade once daily on an empty stomach at least 30 minutes before food, preferably at the same time each day. It is the users obligation to evaluate and use this product safely and to comply with all applicable laws and regulations. Material safety data sheet prepared according to 29 cfr 1910. Msds material data safety sheet 8 gram compressed gas n2o filled charger 1. Sds of deferasirox, safety data sheets, cas 201530418. Hazard identification classification according to regulation no 12722008ec company.
Wash hands before breaks and at the end of workday. In case of contact, immediately flush skin with plenty of water. A safety data sheet sds, material safety data sheet msds, or product safety data sheet psds are documents that list information relating to occupational. Product name deferasirox product code sc207509 cas no 201530418 pure substancemixture substance 1.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Material safety data sheet associated industries inc. May 06, 2015 this is a randomized, openlabel, multicenter, two arm, phase ii study to evaluate treatment compliance and change in serum ferritin of a deferasirox granule formulation and a deferasirox dt formulation in children and adolescents aged. Please note that preregistration is required to buy reference standards. Deferasirox has a survival benefit for sio leukemia murine model in terms of iron chelation and antileukemic therapy3. Relevant identified uses of the substance or mixture and uses advised against for research use only. Feb 20, 2020 have a hearing test before starting this medicine deferasirox tablets and while you take this medicine deferasirox tablets. Nov 18, 2019 a trial conducted in treatment naive pediatric patients, 2 to deferasirox tablets for oral suspension, 125 mg, 250 mg, and 500 mg.
An orally active iron chelator, it is used to manage chronic iron overload in patients receiving longterm blood transfusions. Exjade deferasirox tablets for oral suspension prescribing information. Mds and chronic iron overload due to blood transfusion have. Find out more about the pharmaceutical components and active ingredients that we have on offer for the pharma and veterinary industries.
M of deferasirox for 24 or 48 h, and proliferation is determined by an mtt assay2. It is the first oral medication approved in the usa for this purpose. These products are carbon oxides co, co2, and other toxic compounds nitrogen oxides, isocyanate vapors. The msds is a detailed informational document prepared by the manufacturer or importer of a hazardous chemical.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Cefuroxime axetil api dmfs us drug master file dmf. Download product insert pdfdownload safety data sheet sds pdf. The potential of deferasirox as a novel therapeutic modality. Handling and storage precautions for safe handling. Ips corporation 17109 south main street, gardena, ca 902483127 p. Deferasirox can be prepared from simple commercially available starting materials salicylic acid, salicylamide and 4hydrazinobenzoic acid in the following twostep synthetic sequence. Buy deferasiroxd4 cas 13425758, a labeled tridentate iron chelator, from santa cruz. We believe the information it contains to be correct but cannot guarantee its accuracy or completeness. Deferasirox cas 201530418 scbt santa cruz biotechnology. Deferasirox marketed as exjade, desirox, defrijet, desifer, rasiroxpine and jadenu is an oral iron chelator.
According to the results of its assessment, this substance is not a pbt or a vpvb. Commission regulation eu no 2015830 of 28 may 2015. If you are 55 or older, use this medicine deferasirox tablets with care. Two molecules of deferasirox are capable of binding to 1 atom of iron which are subsequently eliminated by fecal excretion. It describes the physical and chemical properties of the product. The information provided in this material safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Since the ic 50 of deferasirox at 72 h was the lowest in ags cells less than 10. List of drug master files dmf of deferasirox active pharmaceutical ingredient api submitted to the u.
Have eyes examined and tested by medical personnel. Deferasirox api dmfs us drug master file dmf details. The information and recommendations contained herein are based upon data believed to be correct. Material safety data sheet msds for nonfat dry milk i. Deferasirox is rapidly absorbed following oral administration, reaching peak plasma concentrations at 1.
Study to evaluate treatment compliance, efficacy and safety. The recommended initial daily dose of exjade is 20 mgkg body weight. Msds material data safety sheet 8 gram compressed gas n2o. Product identifier product name deferasirox product number fb20882. Export data and price of deferasirox under hs code 2933 zauba. Our azelaic acid is 100% based on vegetable oil sunflower oil or distel oil cardiano mariano. Deferasirox is highly protein bound 99%, almost exclusively to. Controlled clinical trials of exjade in patients with myelodysplastic syndromes. This material safety data sheet and the information it contains are offered to you in good faith as accurate.
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